The referee consulted his assistant behind the goal and chose to show Ronaldo a straight red card, with the contact he made with Murillo's head likely to be the reason for the sending off. The five-time world player of the year was clearly distraught as he left the pitch, still shaking his head.
But his first match in the competition for his new club lasted less than half an hour on Wednesday as he was sent off after appearing to pull at an opponent's hair. And in case of "serious offences", a UEFA Control, Ethics and Disciplinary Body could increase the punishment and even extend it to other competitions.
Murillo hit the deck after a collision with Ronaldo and it remains unknown whether it was the initial clash or Ronaldo's reaction that resulted in the reigning Ballon d'Or holder's red card.
Allegri predicts Ronaldo will break his duck in next game
Ronaldo could well have finished the game with a hat-trick but saw two gilt-edged chances go wide of the post. But Ronaldo won't steal all the headlines from this particular game.
Valencia were unable to make their extra man count and to compound their frustration, Daniel Parejo saw a stoppage time penalty saved by Juventus keeper, Wojciech Szczesny.
The Champions League trophy had barely been presented last May when the ground under began to shift under European soccer.
From amps to microwaves, Amazon tipped to reveal more Alexa devices
If the new devices are made and sold by Amazon, they would be in direct competition with similar devices made by Sonos and Garmin. And in its most recent earnings report, Amazon CEO Jeff Bezos hinted at his ambition for making Alexa more widely used.
When asked if losing Ronaldo would hurt Los Blancos, Alves told Marca: 'I think that, contrary to what everybody else says, Madrid are more of a team without Cristiano, and now it's a little more hard than it was before - at least because of how I see football and my concept of this game'.
Captain Paul Pogba produced an outstanding performance garnished by two goals to help Manchester United to a resounding 3-0 win at Swiss debutants Young Boys.
Flights cancelled in the US Southeast as Hurricane Florence approaches
If the storm makes landfall as a Category 2, these winds will be damaging, sustained at up to 160km/h or so with higher gusts. Tropical Storm Florence continued to dump torrential rainfall on the Carolinas, posing a deadly flooding threat for millions.