Barca will hope the injury to their star player is not serious, particularly with a handful of hard fixtures coming up.
This is a game in which Barcelona wouldn't really miss Messi's presence, considering he would have made way for the bench warmers, anyway.
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Real will look to the Champions League to provide a much-needed confidence boost at home to Czech club Viktoria Plzen on Tuesday, before they head into the crunch clash with Barcelona.
At first Barca seemed unconcerned by Messi's injury, with Ousmane Dembele taking an age to warm up.
Inter recently got the better of their city rivals, AC Milan, in the local derby and is now third in Serie A. It was a Messi masterclass that propelled Barca past a risky Tottenham in his club's last Champions League outing.
"We will miss him, win or lose, but we want to miss him winning".
"We had a great September before the global break and we had to win to stay on this path, so we could arrive at Barcelona with this mentality, which is very important for us", Icardi added. Luis Suarez added the third by converting a second-half penalty kick.
'Now This' news video about Warren's DNA Test, features ICT’s Vincent Schilling
They'll cover for Warren fibbing about her ancestry. "I feel betrayed because she wasn't". President Trump has repeatedly mocked Warren for claiming she is part Native American.
Sevilla got a goal back with the help of a huge deflection with a little over 10 minutes to go as Sarabia's shot struck ex-Sevilla man Clement Lenglet and looped into the far corner.
Real Madrid, who welcome them to the Bernabeu next weekend, are fifth after falling to another defeat - this time at home to Levante - earlier in the day.
Lopetegui, only three months into his stint with Real Madrid, defended himself against the critics.
Madrid defender Marcelo said the players were behind Lopetegui.
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Red Dead Redemption 2 will come to the PlayStation 4 and Xbox One on October 26, 2018 for PlayStation 4 and Xbox One . Rockstar's support page clarifies that the total download size for Xbox One is 107GB, and 99GB for PlayStation 4.