In the wake of the vote, she said the government had a "renewed mission to deliver the Brexit people voted for" and vowed to "assuage the concerns that members of parliament have" on the backstop by winning reassurances in Brussels on Thursday.
Addressing the handbagging she gave the European Union leader, Mrs May admitted it had been tense but said she felt she could speak to him openly.
May said a new leader would not have time to renegotiate Brexit and secure parliamentary approval by the end of March, meaning the Article 50 withdrawal notice would have to be extended or rescinded. "Indeed it is the only deal that is capable of getting through my parliament", she told them.
May responded to a no-confidence vote with a passion she reserves for when her back is against the wall, defending her Brexit deal and warning that ousting her could derail the whole process.
"They have got to say to the European Union. we are not committed to this £39bn unless we get some resolution".
Speaking after the meetings in Brussels, European leaders appeared to express frustration with the inconsistency and vagueness of the UK's position, something May's critics on both the right and left have also complained of.
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City's director of football Txiki Begiristain added: "We are delighted to have secured Phil for the next five and a half years". Chelsea boss Maurizio Sarri has also stated he wants the player to stay on.
"The signals we heard yesterday were not particularly reassuring on Britain's capacity to honour the commitments that were made", said Belgian Prime Minister Charles Michel.
"Theresa May has led a courageous fight, but unfortunately we are not seeing the results": EU Commission President Jean-Claude Juncker.
Footage of the opening of Friday's talks showed May in a tense head-to-head with Juncker.
Theresa May was reportedly furious at Juncker branding the Brexit debate in Britain "nebulous" - vague or ill-defined - thinking it was a criticism of her.
"I don't expect an immediate breakthrough but what I do hope is that we can start to work as quickly as possible on the assurances that are necessary", she said.
"I was surprised to see a demonstration, if you can call it that, with [representation from the] Green Party and discredited Liberal Democrat Party".
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Once, Trump asked her to follow him to the clubhouse where he ran his fingers over picture frames and tables checking for dust. It also broadly contradicts Trump's xenophobic, fear-mongering rhetoric about illegal immigrants at large.
In response, the PM said: "I had a robust discussion with Jean-Claude - I think that's the sort of discussion you're able to have when you have developed a working relationship and you work well together".
The key question is whether the Prime Minister will stand up to them or whether she will roll over as has happened previously.
But several other leaders defended May.
Lawmakers said she told them she recognised that the party did not want her to lead them into the next election, a gesture that could help her win over some wavering MPs on Wednesday night.
The Prime Minister said further talks would take place in the coming days on measures she hopes will persuade MPs to back the agreement in Parliament.
European negotiators are still not completely clear on what the UK's plan is, and amid the lack of clear majority at Westminster for any Brexit scenario other than remaining in the Single Market & Customs Union, confusion keeps mounting. May nevertheless welcomed the short joint statement. Instead less than half of all MPs chose to put their own future ahead of the country's and ours. If she does survive the vote, May will be immune from any new leadership challenge for one year.
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However, he said that if the outcome would not have been changed, the Republican candidate should be certified the victor . Woodhouse defended Harris, calling him a "good man" and said there's "no way he knew about this stuff and sanctioned it".
Vague prospects of cosmetic reassurances don't change the fact that the Prime Minister will come back to the United Kingdom empty-handed, when she could have come back with a new deal securing membership of the Single Market & Customs Union.