Juventus have the edge on away goals thanks to Ronaldo's 125th Champions League goal in a 1-1 draw in Amsterdam, but Ajax's David Neres ensured the teams will start on a knife-edge in Turin in a repeat of the 1973 and 1996 finals.
Manchester United now sit fifth in the Premier League (with an outstanding game) as they battle Arsenal, Chelsea and Tottenham for two spots in the top four.
"I don't know what the team of United's is going to do, but we do know that we have examples of what they have done in the Champions League away from home this season".
Juventus need only a draw to clinch the title and then can focus on the return leg against Ajax on Tuesday.
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"If we had put all our regulars in it would have been easier to win it, but there is also the goal to obtain on Tuesday".
Mattia Perin replaced Wojciech Szczesny in the Juventus goal with Kean getting his second start alongside Paulo Dybala up front. "Everyone did well, we're only sorry for the defeat, but we paid for inexperience".
Much of the belief that United can overturn the first-leg deficit has centred on the Premier League club's impressive last-16 fightback against Paris Saint-Germain, as well as their famous triumph over Bayern Munich in the 1999 final when now-manager Ole Gunnar Solskjaer scored a stoppage-time victor at Camp Nou. "However, I will line up a tough and fair team for the challenge that awaits us". It could be one of those games where the visitors are chasing the ball for much of the game and the players may cut some pretty frustrated figures by the end of it.
And SPAL equalised on 49 minutes, with defender Bonifazi heading in from a corner, before Floccari completed the comeback 16 minutes from time when he swept home from 12 yards.
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Then, Jordi Alba, Philippe Coutinho and Arthur Melo played some minutes in the second half.
SPAL, meanwhile, moved up to 13th in the table with the three points - seven clear of the bottom three.
Ronaldo was rested for the second time this season and the club fell to just their second defeat of the campaign.
Sevilla is in fourth place, the final Champions League spot.
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